Aspirin Facilitates Fenbendazole Bioavailability

Experimental Co-Crystals of Salicylic Acid Increase Solubility by 800%

Fenbendazole Can Cure Cancer presents Case Reports of people who have treated their own cancers along with other articles to help understand how fenbendazole works to treat cancer. Previous articles covering other cancers are in the Archives link.

Scientists from India have published a recent paper exploring methods to better dissolve fenbendazole in an attempt to make the life saving drug more bioavailable. In an article titled Cocrystals of Fenbendazole with Enhanced in vitro Dissolution Performance published in the European Chemical Bulletin, Priyanka KB, et al. has found simple substances can make fenbendazole more likely to reach its target. In simple terms, this study tackles a major problem with the drug fenbendazole: it doesn't dissolve well in water.

The Problem: Think of a drug you swallow like sugar you stir into coffee. If the sugar doesn't dissolve, it just sinks to the bottom, and your coffee doesn't get sweet. Similarly, if a drug doesn't dissolve in the fluids of your stomach and intestines, your body can't absorb it into the bloodstream. If it's not absorbed, it can't get to the cells where it might have an effect. This problem is called “poor dissolution” or “low bioavailability.” For fenbendazole users, this is a significant hurdle.

The Researchers' Goal: The scientists wanted to find a way to make fenbendazole dissolve better, so that more of it could potentially be absorbed by the body.

Their Solution: They created something called a “co-crystal.” This is a sophisticated technique where they take the fenbendazole molecule and pair it with another safe, simple molecule (in this case, things like malonic acid or salicylic acid). Salicylic acid is a metabolic byproduct of common aspirin (acetylsalicylic acid). By crystallizing these two molecules together in a specific, ordered structure, they essentially create a new solid form of the drug with different properties.

What they Found: The researchers tested how well their new fenbendazole cocrystals dissolved compared to the original, pure fenbendazole powder. They placed both in a lab solution that mimics the conditions inside the human digestive system

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• The original fenbendazole powder performed very poorly. After 90 minutes, only about 10% of it had dissolved.
• The new fenbendazole cocrystals performed dramatically better. After 90 minutes, around 85% of the drug had dissolved.

Conclusion: The study successfully showed that creating cocrystals of fenbendazole is a highly effective way to dramatically improve how quickly and completely it dissolves in a lab setting. This suggests that if this form of the drug were taken orally, the body would have a much better chance of absorbing it.

How This May Affect the Oral Administration of Fenbendazole for Self-Treaters

This study provides important scientific validation for a key challenge that people in online fenbendazole communities have been trying to solve: getting the drug into the body effectively.

Here’s how the data and conclusions might affect thinking about the oral administration of fenbendazole:

1. It Confirms That “Just Taking Fenbendazole” Is Inefficient but Not Ineffective.

The study’s most critical finding for a self-treater is the stark difference in dissolution: 10% vs. 85%. This provides scientific evidence that simply swallowing pure fenbendazole powder or the granules from veterinary products likely results in most of the drug passing through your body without ever being absorbed. This validates the concern that the form in which you take the drug is incredibly important.

It does not however speak to the effectiveness of that 10% that apparently does become available to be absorbed. That is, even though there are issues with achieving ideal absorption, the fact is fenbendazole still eradicates cancer, despite non-ideal absorptive conditions, at those minimized doses is noteworthy and my provide guidance regarding future studies on ideal dosing protocols.

2. It Highlights the Importance of “Bioavailability.”

The entire point of creating cocrystals was to increase the drug's bioavailability (the amount that enters the bloodstream). This research powerfully underscores that any attempt to use fenbendazole should be focused on maximizing its absorption. The informal advice often seen in online forums—such as taking fenbendazole with a fatty meal, oils (like coconut or olive oil or butter), or other supplements—are all attempts to solve this same bioavailability problem. This paper presents a more advanced, pharmaceutical-grade solution to that exact issue.

3. Practical Application: You Cannot Make Cocrystals at Home.

This is a key takeaway. The process described in the paper is a precise laboratory technique requiring specific chemicals, equipment, and expertise. It is not something that can be replicated in a kitchen. Therefore, the direct, practical application of this study is limited. You cannot buy “fenbendazole cocrystals” as a product, nor can you make them yourself.

4. The Core Principle, Not the Specific Method, is Key.

While you can’t use the study’s method (cocrystals), you can understand its principle : the physical form of fenbendazole must be altered to improve dissolution. This reinforces the idea that fenbendazole should not be taken on its own with just water. The study scientifically supports the underlying logic behind combining it with fats or other agents that can help it dissolve and be absorbed.

In a Nutshell:

This paper scientifically proves that regular fenbendazole is usually poorly absorbed. It demonstrates a sophisticated lab method (cocrystals) to fix this, resulting in an 8-fold increase in how much of the fenbendazole dissolves.

For someone self-treating their cancer with fenbendazole, this means:

1. It validates the fundamental problem that much of the fenbendazole that is taken is likely doesn't get absorbed.

2. It emphasizes that a primary focus should be on finding safe ways to increase its absorption (bioavailability).

3. While the specific “cocrystal” solution is not available to you, the study provides strong scientific reasoning for why methods like taking fenbendazole with fats are explored in patient communities, as they are all attempts to solve the same core issue of poor dissolution.

Does this Paper Suggest that Fenbendazole Should be Taken with an Aspirin?

It does not directly suggest that because application of the findings to human use was not the purpose of the study. However, for our purposes here this study does seem to suggest that salicylic acid helps with fenbendazole bioavailability. Aspirin (acetylsalicylic acid), when it is metabolized in the body is converted into salicylic acid. So we have the exact substance that was studied in this cocrystal paper as a main metabolite of aspirin.

Fortunately we don’t have to wait for guidance because we have a pool of successful fenbendazole users to consult. Since many of our Case Reports involve people age 50 and above it is likely that many could have already be on some type of low dose aspirin regimen for cardiovascular health. We informally surveyed those who’ve submitted case reports as to whether they were also taking aspirin of any kind at the same time they were self-treating with fenbendazole. So far, the overwhelming response is Yes.

So there we have it! Anecdotal evidence from some of those that have eradicated their cancers using fenbendazole also appeared, coincidentally, to be taking aspirin at the same time. Whether taking the aspirin made a critical difference in their outcome remains to be seen. However, given the findings of the above co-crystal study, the case report survey and the low risk/high reward proposition in combining aspirin into a fenbendazole protocol, incorporating aspirin may be something to consider for those that don’t have specific medical reasons to avoid aspirin.

Priyanka KB, Ramya TS, Swarnalatha K, Sushmitha G, Ara A, Srujana TS, Swapna B: Cocrystals of fenbendazole with enhanced in vitro dissolution performance. Eur Chem Bull 12(8): 9056-9061, 2023. DOI: 10.31838/ecb/2023.12.Si8.826

Items Included in All Posts

Fenbendazole vs. Mebendazole vs. Albendazole vs. Flubendazole: The benzimidazoles are very similar chemically and they have very similar mechanisms of action with respect to disrupting microtubule function, specifically defined as binding to the colchicine-sensitive site of the beta subunit of helminithic (parasite) tubulin thereby disrupting binding of that beta unit with the alpha unit of tubulin which blocks intracellular transport and glucose absorption (Guerini et al., 2019). If someone asks you how fenbendazole kills the cancer cells, the answer is in italics in the previous sentence.

The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole. Mebendazole is the form that is approved for human use while fenbendazole is approved for veterinary use. The main difference is the cost. Mebendazole is expensive ~$555 per 100 mg pill, while fenbendazole is inexpensive ~48 cents per 222 mg free powder dose (Williams, 2019). As you may recall, albendazole is the form used to treat intestinal parasites in India and these cost 2 cents per pill. FYI, to illustrate how Americans are screwed by Big Pharma, two pills of mebendazole cost just $4 in the UK, 27 cents per 100 mg pill in India and $555 per 100 mg pill in the US.

While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually all of the self-treating clinical reports involve the use of fenbendazole. Because the pre-clinical cancer studies use mebendazole (ironically the human form of fenbendazole) and humans self-treat their cancers with fenbendazole (the animal form of mebendazole) it is very reasonable to assume that mebendazole and fenbendazole are functional equivalents with respect to cancer. It would be helpful if future pre-clinical and clinical investigations simply used fenbendazole as a practical matter. For the purposes of this Substack, fenbendazole, mebendazole and albendazole are used interchangably.

Where to get fenbendazole
In our experience and the experiences of those that write in, it appears that the three readily available brands of fenbendazole (Panacur-C, FenBen Labs, Happy Healing Labs) are equally effective. Panacur-C can be obtained locally in pet stores, while they all can be obtained from Amazon. The article on Questions & Answers discusses the brands of fenbendazole in detail and shows photos of the various brands referenced.

If you would like to report your experiences with fenbendazole you can do so privately by email myfenbendazole@proton.me or more publicly in the Comments section in any of the articles. Also, if you know of people who’ve tried fenbendazole, and it didn’t work, we’d be especially interested in hearing from you now. Understanding the conditions and factors that enhance or impede the success of fenbendazole in treating cancer are valuable.

Disclaimer:
Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. This website does not provide any kind of health or medical advice of any kind. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The case reports presented reflect the real-life experiences and opinions of other readers or users of the website. The experiences of those readers or users are personal to those particular readers/users and may not necessarily be representative of all readers/users. We do not claim, and you should not assume, that all other readers/users will have the same experiences. Do you own research, consult with relevant medical professionals before attempting to self-treat for any condition.